Recombinant Human FLT (V320-D469) is produced by our Mammalian expression system and the target gene encoding Val320-Asp469 is expressed with a FLAG and a 6His tag at the C-terminus.
Recombinant Human FLT (V320-D469)
SKU: BP236-10ug
$116.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
Less than 0.1 EU/ug
Accession Number
P36888
Species
Human
Expression System
Human 293 Cells
Target Sequence
Val320-Asp469
Tag
C-FLAG-6His
Formulation
Supplied as a 0.2 um filtered solution of PBS, pH7.4
Packaging
Dry ice/ice pack
Background
Tyrosine-protein kinase acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and dendritic cells. It stimulates phosphorylation of SHC1 and AKT1, and activates the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. It can be used as a diagnostic tool to establish the exact cause of acute myeloid leukemia and to determine the optimal therapy.
Purity
greater than 75% as determined by reducing SDS-PAGE.
Receptor-type tyrosine-protein kinase FLT3, CD135, STK-1, FLK-2
Alternative Names
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Citation
NA
Activity
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