Recombinant Human Epidermal Growth Factor Receptor/EGFR/ErbB1/HER1 (C-Fc)

Recombinant Human Epidermal Growth Factor Receptor/EGFR/ErbB1/HER1 (C-Fc)

SKU: CI54-10ug
Recombinant Human EGFR is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a Fc tag at the C-terminus. Bon Opus Cat. #CI54
  • Accession Number

  • Background

    EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
  • Expression

    Human Cells
  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
  • ALTnames

    Epidermal growth factor receptor,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,EGFR,ERBB, ERBB1, HER1
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