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Recombinant Human ENPP-2/LysoPLD (C-6His)

SKU: CW02-10ug
$105.00Price
Recombinant Human Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 is produced by our Mammalian expression system and the target gene encoding Ala36-Ile863 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CW02
Size
  • Accession Number

    Q13822
  • Background

    ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain.Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
  • Expression

    Human Cells
  • Packaging

    Ambient
  • Formulation

    Lyophilized from a 0.2 μm filtered solution of 20mMPB,150mMNaCl,pH7.4.
  • ALTnames

    ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2;E-NPP 2; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2