Recombinant Human Endothelial Protein C Receptor is produced by our Mammalian expression system and the target gene encoding Ser18-Ser210 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C340

Recombinant Human Endothelial Protein C Receptor/EPCR/PROCR/CD201 (C-6His)

Name: Recombinant Human Endothelial Protein C Receptor/EPCR/PROCR/CD201 (C-6His)
SKU: C340-10ug

SKU: C340-10ug

$110.00

Quantity

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Email: orders@bonopusbio.com

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

Q9UNN8

Species

Human

Expression System

Human Cells

Target Sequence

Ser18-Ser210

C-His

Formulation

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Packaging

Ambient

Background

Endothelial Protein C Receptor (EPCR) is a Vitamin K-dependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (Protease-Activated Receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the Thrombin-Thrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.