Recombinant Human Disks Large Homolog 4/DLG4/PSD95 (N-6His)
Recombinant Human Postsynaptic Density Protein 95 is produced by our E.coli expression system and the target gene encoding Met1-Leu724 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #CH23
BackgroundDisks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesDisks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, PSD95, DLG4