BackgroundHuman Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 200mM NaCl, 1mM DTT, pH 8.0.
ALTnamesDynein Light Chain 1 Cytoplasmic, 8 kDa Dynein Light Chain, DLC8, Dynein Light Chain LC8-Type 1, Protein Inhibitor of Neuronal Nitric Oxide Synthase, PIN, DYNLL1,DLC1, DNCL1, DNCLC1, HDLC1