Recombinant Human Contactin-2/CNTN2/TAG-1 (C-6His)
Recombinant Human Contactin-2 is produced by our Mammalian expression system and the target gene encoding Ser31-Asn1012 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CJ24
BackgroundContactin-2 (CNTN2) is encoded by the CNTN2 gene,which belongs to the immunoglobulin superfamily and contactin family. It contains 4 fibronectin type-III domains and 6 Ig-like C2-type domains. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. CNTN2 may play a role in the formation of axon connections in the developing nervous system. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
FormulationLyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
ALTnamesContactin-2, Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, CNTN2, AXT, TAG1, TAX1