Recombinant Human Complement Factor H/CFH (C-6His)

Recombinant Human Complement Factor H/CFH (C-6His)

SKU: CI77-10ug
Recombinant Human Complement factor H is produced by our Mammalian expression system and the target gene encoding Glu19-Leu449 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CI77
  • Accession Number

  • Background

    Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.
  • Expression

    Human Cells
  • Packaging

    Dry ice/ice packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of PBS,20%Glycerol,5% Trehalose,pH7.4.
  • ALTnames

    Complement factor H
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