Recombinant Human CEACAM5/CD66e/CEA (C-6His)
Recombinant Human CEACAM5 is produced by our Mammalian expression system and the target gene encoding Lys35-Ala685 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CM95 (BP134)
BackgroundCarcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesCarcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100, CD66e, CEACAM5