Recombinant Human CD20/MS4A1 (N-Trx-6His)
Recombinant Human B-lymphocyte Antigen CD20 is produced by our expression system and the target gene encoding Ile141-Ser188 is expressed with a Trx, 6His tag at the N-terminus. Bon Opus Cat. #CF41
BackgroundCD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells.It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5).
FormulationLyophilized from a 0.2 μm filtered solution of 50mMTris,150mMNaCl,1mMEDTA,pH8.0.