Recombinant Human CD14 is produced by our Mammalian expression system and the target gene encoding Thr20-Cys352 is expressed with a 6His tag at the C-terminus.
Recombinant Human CD14 (C-His)
SKU: BP241-10ug
$88.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
Please contact us to order for international shipments.
Endotoxin
less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P08571
Species
Human
Expression System
Human 293 Cells
Target Sequence
Thr20-Cys352
Tag
C-6His
Formulation
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4
Packaging
Ambient
Background
CD14 is a cell surface glycoprotein that is selectively expressed on monocytes, macrophages, and activated granulocytes. CD14 is a component of the innate immune system. It exists in two forms. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and acts as a pattern recognition receptor that binds lipopolysaccharides (LPS) and various ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS binding protein (LBP). Toll-like receptors have also been implicated in the transduction of CD14-LPS signals. Soluble CD14 can be released from the cell surface by phosphatidyinositol-specific phospholipase C and has been found in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.
Purity
95% SDS-PAGE
Monocyte Differentiation Antigen CD14; Myeloid Cell-Specific Leucine-Rich Glycoprotein; CD14
Alternative Names
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Citation
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Activity
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