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Recombinant Human Carbonic Anhydrase 4/CA4 (C-6His)

Recombinant Human Carbonic Anhydrase 4/CA4 (C-6His)

SKU: C109-10ug
$158.00Price
Recombinant Human Carbonic Anhydrase 4 is produced by our E.coli expression system and the target gene encoding Ala19-Lys283 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C109
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P22748
Species
Human
Expression System
E.coli
Target Sequence
Ala19-Lys283
Tag
C-His
Formulation
Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.5.
Packaging
Dry ice/Polar packs
Background
Carbonic Anhydrase 4 (CA4) belongs to the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic anhydrase 4 is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Carbonic anhydrase 4 may stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It may have a role in inherited renal abnormalities of bicarbonate transport. Furthermore, Carbonic anhydrase 4 is essential for acid overload removal from the retina and retina epithelium and acid release in the choriocapillaris.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Carbonic Anhydrase 4; Carbonate Dehydratase IV; Carbonic Anhydrase IV; CA-IV; CA4
Alternative Names
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Citation
NA
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