Recombinant Human Carbonic Anhydrase 4/CA4 (C-6His)
Recombinant Human Carbonic Anhydrase 4 is produced by our E.coli expression system and the target gene encoding Ala19-Lys283 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C109
BackgroundCarbonic Anhydrase 4 (CA4) belongs to the alpha-carbonic anhydrase family. Alpha-carbonic anhydrase is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. Carbonic anhydrase 4 is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Carbonic anhydrase 4 may stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It may have a role in inherited renal abnormalities of bicarbonate transport. Furthermore, Carbonic anhydrase 4 is essential for acid overload removal from the retina and retina epithelium and acid release in the choriocapillaris.
PackagingDry ice/Polar packs
FormulationSupplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, pH 8.5.
ALTnamesCarbonic Anhydrase 4, Carbonate Dehydratase IV, Carbonic Anhydrase IV, CA-IV, CA4