Recombinant Human Cadherin-1 is produced by Human 293 Cells. The target gene encoding Q23-A709 is expressed with a 8His tag at the C terminus.
Recombinant Human Cadherin-1/E-cadherin/CDH1 (C-His)
SKU: BP099-50ug
$158.00Price
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Shipping Information
$48 Standard Overnight flat rate for products shipped in room temperature within the United States.
Additional $27 Ice Packs shipment fee is required for liquid proteins.
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Endotoxin
less than 0.1 ng/ug (1 EU/ug) as determined by TAL test.
Accession Number
P12830
Species
Human
Expression System
Human 293 Cells
Target Sequence
Q23-A709
Tag
C-8His
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH7.2
Packaging
Ambient
Background
E-Cadherin is a calcium-dependent cell adhesion glycoprotein that belongs to the cadherin family. E-Cadherin is expressed in non-neural epithelial tissues. It tends to interact with each other in a homophilic manner in connecting cells. E-Cadherin clusters are critical components of adherent junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier. E-Cadherin is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. E-Cadherin loss contributes to cancer metastasis. The extracellular E-Cadherin N-terminal domain can be cleaved by several proteases and is released as a soluble factor that enhances cancer cell motility and EGFR-dependent survival and proliferation.
Purity
greater than 95% as determined by reducing SDS-PAGE.
Cadherin-1; CDH1; CAM 120/80; E-cadherin; CD324
Alternative Names
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Citation
NA
Activity
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