Recombinant Human Bactericidal Permeability Protein/BPI/CAP57 (C-6His)
Recombinant Human CAP57 is produced by our Mammalian expression system and the target gene encoding Val32-Lys487 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CC59
BackgroundBactericidal permeability-increasing protein(BPI for short), is a secreted protein which belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family. It exists as a monomer or a disulfide-linked homodimer. The cytotoxic action of BPI is limited to many species of Gram-negative bacteria. This specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. BPI has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, and this activity is inhibited by LPS from P.aeruginosa.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
ALTnamesBactericidal permeability-increasing protein,BPI,CAP57