Recombinant Human Apolipoprotein E/ ApoE (C-His, Expi293)
Recombinant Human Apolipoprotein E is produced by Human 293 Cells and the target gene encoding Lys19?His317 is expressed with a 6His tag at the C?terminus.
ExpressionHuman 293 Cells
BackgroundApolipoprotein E (ApoE) is a glycoprotein that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. ApoE can be synthesized by the liver and intestinally synthesized chylomicrons. ApoE mediates high-affinity binding of chylomicrons and very low density lipoprotein (VLDL) particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol-rich particles in the plasma. ApoE plays an essential role in the formation of plasma lipoproteins and is involved in their production, conversion and clearance. ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport.
FormulationLyophilized frum a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.4
ALTnamesAD2; LPG; APO-E; LDLCQ5; apolipoprotein E; apolipoprotein E3