BackgroundAngiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
PackagingDry ice/Polar packs
FormulationSupplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
ALTnamesAngiotensinogen, also called Serpin A8, AGT and SERPINA8, is expressed by the liver and secreted in plasma. Angiotensinogen is a member of the serpin family.