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Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-Fc-6His)
Recombinant Human Activin Receptor IIB is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus. Bon Opus Cat. #CX58

Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-Fc-6His)

SKU: CX58-10ug
$53.00 Regular Price
$42.40Sale Price
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
Q13705
Species
Human
Expression System
Human Cells
Target Sequence
Ser19-Thr134
Tag
C-Fc&His
Formulation
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Packaging
Ambient
Background
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B
Alternative Names
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Citation
Immobilized Human/Mouse/Rat Activin A(Cat#C687) at 5μg/ml (100 μl/well) can bind Human ACVR2B-His(Cat#CX58). The ED50 of Human ACVR2B-His(Cat#CX58) is 10-50 ng/ml .
Activity
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