Recombinant Human Activin Receptor 2A/Activin RIIA/ACVR2A (C-Fc-6His)

SKU: CB60-10ug
$50.00Price
Recombinant Human Activin Receptor IIA is produced by our Mammalian expression system and the target gene encoding Ala20-Pro134 is expressed with a Fc, 6His tag at the C-terminus. Bon Opus Cat. #CB60
Size
  • Accession Number

    P27037
  • Background

    Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
  • Expression

    Human Cells
  • Packaging

    Ambient
  • Formulation

    Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
  • ALTnames

    Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2

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