BackgroundActin-Related Protein 8 (ACTR8) is a member of the Actin family. ACTR8 is the first example in actin family that was found to be associated with mitotic chromosomes. ACTR8 plays a vital role in the functional organization of mitotic chromosomes. This protein is a proposed core component of the chromatin remodeling INO80 complex that is involved in transcriptional regulation, DNA replication and probable DNA repair, and it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,1mM DTT,pH7.4.
ALTnamesActin-Related Protein 8, hArp8, INO80 Complex Subunit N, ACTR8, ARP8, INO80N