Recombinant Human ACE2 Protein (C-hFc)
Recombinant Human ACE2 Protein is produced by HEK293. The target gene encoding 18-740 is expressed with a hFc tag at the C terminus.
BackgroundAngiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensin I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor do not inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
FormulationLyophilized frum a 0.2 um filtered solution of PBS, pH7.4
ALTnamesAngiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-ConvertingEnzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2