Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Met393 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #CE50

Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase/4HPPD/HPPDase (N-6His)

Name: Recombinant Human 4-Hydroxyphenylpyruvate Dioxygenase/4HPPD/HPPDase (N-6His)
SKU: CE50-10ug

SKU: CE50-10ug

$158.00

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Accession Number

P32754

Species

Human

Expression System

E.coli

Target Sequence

Met1-Met393

N-His

Formulation

Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 50mM NaCl, 1mM DTT, 0.1mM PMSF, pH 8.0.

Packaging

Dry ice/Polar packs

Background

4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in high levels of tyrosine concentration in the blood, which can cause mild mental retardation at birth, and degradation in vision as a patient grows older.