Recombinant Human β-Ureidopropionase/UPB1 (C-6His)
Recombinant Human beta-Ureidopropionase is produced by our E.coli expression system and the target gene encoding Met1-Glu384 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C210
Backgroundβ-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta aminoisobutyric acid, respectively. Defects in β-Ureidopropionase are the cause of β-Ureidopropionase deficiency that is characterized by muscular hypotonia, dystonic movements, scoliosis, microcephaly and severe developmental delay.
PackagingDry ice/Polar packs
FormulationSupplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
ALTnamesBeta-Ureidopropionase, BUP-1, Beta-Alanine Synthase, N-Carbamoyl-Beta-Alanine Amidohydrolase, UPB1, BUP1