Recombinant Hirudo medicinalis Hirudin-1/Lepirudin (C-His)
Recombinant Hirudo medicinalis Hirudin-1 is produced by Pichia pastoris. The target gene encoding Y3-Q65 is expressed with a 6His tag at the C terminus.
BackgroundHirudin is a secreted protein that belongs to the protease inhibitor I14 (hirudin) family. Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. In nature, Hirudin is found in the salivary glands of Hirudo medicinalis that has a blood anticoagulant property. Hirudin can be used to treat heparin-induced thrombocytopenia.
FormulationSupplied as a 0.2 um filtered solution of PBS pH7.4
PackagingDry ice/ice pack
ALTnamesHirudin-1; Lepirudin; Hirudin variant-1