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Recombinant Cynomolgus TIGIT/VSIG9/VSTM3 (C-6His)
Recombinant Cynomolgus monkey TIGIT is produced by our Mammalian expression system and the target gene encoding Met89-Pro209 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CP02

Recombinant Cynomolgus TIGIT/VSIG9/VSTM3 (C-6His)

SKU: CP02-10ug
$100.00Price
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
G7NXM4
Species
Cynomolgus
Expression System
Human Cells
Target Sequence
Met89-Pro209
Tag
C-His
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Packaging
Ambient
Background
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
Alternative Names
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Citation
NA
Activity
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