Recombinant Cynomolgus Sialic acid-binding Ig-like lectin 5/Siglec-5 (C-6His)

Recombinant Cynomolgus Sialic acid-binding Ig-like lectin 5/Siglec-5 (C-6His)

SKU: CA56-10ug
Recombinant Cynomolgus Siglec-5 is produced by our Mammalian expression system and the target gene encoding Glu17-Gly435 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CA56
  • Accession Number

  • Background

    Sialic acid-binding Ig-like lectin 5 is a protein that in Cynomolgus is encoded by the SIGLEC5 gene, Cynomolgus SIGLEC5 cDNA encodes 551 amino acids (aa) that include a 16 aa signal sequence, a 439aa extracellular domain (ECD) with three Ig-like domains, a transmembrane region and a cytoplasma tail. No Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • Expression

    Human Cells
  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of PBS, pH8.0.
  • ALTnames

    Sialic acid-binding Ig-like lectin 5; Siglec-5
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