Recombinant Macaca fascicularis Cytotoxic and regulatory T-cell molecule is produced by our Mammalian expression system and the target gene encoding Ser18-Gly287 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CB86

Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

Name: Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)
SKU: CB86-10ug

SKU: CB86-10ug

$110.00

Quantity

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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

Additional $27 Ice Packs shipment fee is required for liquid proteins.

Please contact us to order for international shipments.

Certificate of Analysis

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Endotoxin

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Accession Number

A0A2K5TKL4

Species

Cynomolgus

Expression System

Human Cells

Target Sequence

Ser18-Gly287

C-His

Formulation

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.

Packaging

Ambient

Background

Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.