Recombinant Cynomolgus CD160 (C-6His)
Recombinant Cynomolgus CD160 Molecule is produced by our Mammalian expression system and the target gene encoding Met1-Leu158 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CW17
BackgroundCD160 antigen is a cell membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim) CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and smal lintestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesCD160 antigen; Cd160