Recombinant Cynomolgus CD152/CTLA-4 (C-6His)
Recombinant Cynomolgus Cytotoxic T-lymphocyte associated protein 4 is produced by our expression system and the target gene encoding Ala37-Ser160 is expressed Bon Opus Cat. #C957
BackgroundCytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
FormulationLyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
ALTnamesCytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4