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Recombinant Human Transforming Growth Factor β-1/TGFB1
Recombinant Human Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed. Bon Opus Cat. #CA59

Recombinant Human Transforming Growth Factor β-1/TGFB1

SKU: CA59-10ug
$158.00 Regular Price
$110.60Sale Price
Quantity
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Endotoxin
Less than 0.01 EU/ug as determined by LAL test.
Accession Number
P01137
Species
Human
Expression System
CHO Stable Cells
Target Sequence
Ala279-Ser390
Tag
tag free
Formulation
Lyophilized from a 0.2 um filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH2.5.
Packaging
Ambient
Background
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB
Alternative Names
Han, D. J. et al. Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis. Molecular Metabolism 66, 2022
Citation
Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.  The ED50 for this effect is 4-40 pg/ml
Activity
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