Recombinant Human Toll-Interacting Protein/TOLLIP (C-6His)
Recombinant Human Toll-Interacting Protein is produced by our E.coli expression system and the target gene encoding Ala2-Pro274 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CE59
BackgroundToll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins. TOLLIP can negative regulate Toll-like receptors signaling, which may limit the production of proinflammatory mediators during the process of inflammation and infection.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5mM EDTA, pH 7.2.
ALTnamesToll-Interacting Protein, TOLLIP