Recombinant Human pro-Nerve Growth Factor/pro-NGF (Glu19-Ala241)
Recombinant Human pro-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Glu19-Ala241 is expressed. Bon Opus Cat. #C078
BackgroundThe precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.
ALTnamesBeta-Nerve Growth Factor, Beta-NGF, NGF, NGFB, pro NGF