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Recombinant Human Oncostatin M/OSM (N-6His)
Recombinant Human Oncostatin M is produced by our E.coli expression system and the target gene encoding Ala26-Arg221 is expressed with a 6His tag at the N-terminus. Bon Opus Cat. #C099

Recombinant Human Oncostatin M/OSM (N-6His)

SKU: C099-10ug
$158.00Price
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P13725
Species
Human
Expression System
E.coli
Target Sequence
Ala26-Arg221
Tag
N-His
Formulation
Lyophilized from a 0.2 um filtered solution of 20mMTris-HCl,1mMEDTA,200mMNaCl,pH7.5.
Packaging
Ambient
Background
Oncostatin M (OSM) encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological activities through specific cell surface receptors. The low affinity LIF receptor that shares the similarity of containing protein gp130 has now been identified to be a component of a high- affinity OSM receptor that will transduce OSM signals. OSM has also been shown to play a role in both pro and anti-inflammatory actions. OSM may also be involved in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Oncostatin-M; OSM
Alternative Names
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Citation
Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 0.2-1ng/ml.
Activity
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