Recombinant Human Legumain/Asparaginyl Endopeptidase (C-6His)
Recombinant Human Legumain is produced by our Mammalian expression system and the target gene encoding Ile18-Tyr433 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C371
BackgroundLegumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
PackagingDry ice/ice packs
FormulationSupplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH 8.0.
ALTnamesLegumain, Asparaginyl Endopeptidase, Protease Cysteine 1, LGMN, PRSC1