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Recombinant Human Legumain/Asparaginyl Endopeptidase (C-6His)

SKU: C371-10ug
Recombinant Human Legumain is produced by our Mammalian expression system and the target gene encoding Ile18-Tyr433 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C371
  • Accession Number

  • Background

    Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
  • Expression

    Human Cells
  • Packaging

    Dry ice/ice packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH 8.0.
  • ALTnames

    Legumain, Asparaginyl Endopeptidase, Protease Cysteine 1, LGMN, PRSC1