Recombinant Human Ciliary Neurotrophic Factor/CNTF

SKU: C098-10ug
Recombinant Human CNTF is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed. Bon Opus Cat. #C098
  • Accession Number

  • Background

    Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
  • Expression

  • Packaging

  • Formulation

    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM Cysteine, pH 7.4.
  • ALTnames

    Ciliary Neurotrophic Factor, CNTF

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