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Recombinant Human CD47/IAP/OA3 (C-6His)
Recombinant Human CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C321 (BP043)

Recombinant Human CD47/IAP/OA3 (C-6His)

SKU: C321-10ug
$84.00Price
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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
Q08722
Species
Human
Expression System
Human Cells
Target Sequence
Gln19-Pro139
Tag
C-His
Formulation
Lyophilized from a 0.2 um filtered solution of 10mM Tris-Citrate,150mM NaCl,pH8.0.
Packaging
Ambient
Background
CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Leukocyte Surface Antigen CD47; Antigenic Surface Determinant Protein OA3; Integrin-Associated Protein; IAP; Protein MER6; CD47; MER6
Alternative Names
Yao, M. et al. Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models. Biomedicines 9(6), 2021
Citation
Immobilized Human SIRPA-Fc (Cat#CP67) at 10μg/ml (100 μl/well) can bind Human CD47-His (Cat#C321). The ED50 of Human CD47-His(Cat#C321) is 13-89 ng/ml .
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