Recombinant Human 15-PGDH/HPGD (C-6His)

Recombinant Human 15-PGDH/HPGD (C-6His)

SKU: C848-10ug
Recombinant Human HPGD is produced by our Mammalian expression system and the target gene encoding Met1-Gln266 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #C848
  • Accession Number

  • Background

    15-hydroxyprostaglandin dehydrogenase [NAD(+)], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.
  • Expression

    Human Cells
  • Packaging

    Dry Ice/ice packs
  • Formulation

    Supplied as a 0.2 μm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.
  • ALTnames

    15-Hydroxyprostaglandin Dehydrogenase [NAD(+)], 15-PGDH, Prostaglandin Dehydrogenase 1, HPGD, PGDH1
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