LinkLight™ U2-OS PTH1R / β-arrestin Cell Line
LinkLight™ U2-OS PTH1R / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human PTH1R pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method. Bon Opus Cat. #BC050054
BackgroundPTH1R acts as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). It is a member of the G-protein coupled receptor family 2. Activity is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.
PackagingShip on Dry Ice