LinkLight™ U2-OS ASK1 / 14-3-3 Human Kinase Cell Line
LinkLight™ U2-OS ASK1 / 14-3-3 Human Kinase Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human ASK1 pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method. Bon Opus Cat. #BC050078
BackgroundASK1, also known as MAP3K5, contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
PackagingShip on Dry Ice
ALTnamesMAP3K5, MEKK5, Mitogen-activated protein kinase kinase 5, apoptosis signal-regulating kinase 1, ASK1, ASK 1