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Biotinylated Human PD-1 (C-6His-Avi)
Biotinylated Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His, Avi tag at the C-terminus.

Biotinylated Human PD-1 (C-6His-Avi)

SKU: CY18-20ug
$302.00Price
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Shipping Information

$48 Standard Overnight flat rate for products shipped in room temperature within the United States.

 

Additional $27 Ice Packs shipment fee is required for liquid proteins.

 

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Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
Q15116
Species
Human
Expression System
Human Cells
Target Sequence
Pro21-Gln167
Tag
C-6His-Avi
Formulation
Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
Packaging
Ambient
Background
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Programmed cell death protein 1;hPD-1;PDCD1;CD279
Alternative Names
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Citation
NA
Activity
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