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Biotinylated Human IL-5 (C-6His-Avi)

Biotinylated Human IL-5 (C-6His-Avi)

SKU: CY67-20ug
$302.00Price
Biotinylated Recombinant Human Interleukin-5 is produced by our Mammalian expression system and the target gene encoding Ile20-Ser134 is expressed with a 6His, Avi tag at the C-terminus.
Endotoxin
Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Accession Number
P05113
Species
Human
Expression System
Human Cells
Target Sequence
Ile20-Ser134
Tag
C-6His-Avi
Formulation
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Packaging
Ambient
Background
IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Interleukin-5;IL-5;B-cell differentiation factor I;Eosinophil differentiation factor;T-cell replacing factor;TRF;IL5
Alternative Names
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Citation
NA
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