Anti-2019-nCoV S1 mAb (5D9)
SKU: NC025-1mg
$750.00Price
Antibody recognizes 2019-nCoV S1 Protein/ 2019-nCoV S-RBD Protein.
Size
Immunogen
2019-nCoV S1 Protein/ 2019-nCoV S-RBD ProteinIsotype
Human IgG1Packaging
LiquidFormulation
PBS, pH 7.4Application Summary
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.Host Species
Cultured in vitro under conditions free from animal derived components