Anti-2019-nCoV S1 mAb (5D9)

Anti-2019-nCoV S1 mAb (5D9)

SKU: NC025-1mg
Antibody recognizes 2019-nCoV S1 Protein/ 2019-nCoV S-RBD Protein.
  • Immunogen

    2019-nCoV S1 Protein/ 2019-nCoV S-RBD Protein
  • Isotype

    Human IgG1
  • Packaging

  • Formulation

    PBS, pH 7.4
  • Application Summary

    The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
  • Host Species

    Cultured in vitro under conditions free from animal derived components
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