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ZO2 Rabbit polyclonal Antibody IgG

SKU: BA110729-100µl
$279.00Price

Fig1: Western blot analysis on cell lysates using anti-ZO2 rabbit polyclonal antibodies.

Fig2: ICC staining ZO2 in A431 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

 

Bon Opus Cat. #BA110729
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Tight junction protein ZO-2,Tight junction protein 2,Zona occludens protein 2,Zonula occludens protein 2
  • Background

    Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces. Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton. ZO-1 and -2 are required for tight junction formation and function. In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators.(R1402-2)