WNT3A Mouse monoclonal Antibody IgG2b
Fig1: Western blot analysis of WNT3A on human WNT3A recombinant protein using anti-WNT3A antibody at 1/1,000 dilution.
Fig2: Western blot analysis of WNT3A on HEK293 (1) and WNT3A-hIgGFc transfected HEK293 (2) cell lysate using anti-WNT3A antibody at 1/1,000 dilution.
Fig3: Western blot analysis of WNT3A on different cells lysate using anti-WNT3A antibody at 1/1,000 dilution.
Positive control: Line1: A549 Line2: HepG2 Line3: A431
Host Species; Species ReactivityMouse; Human
Application SummaryWB, ICC, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesT-cell differentiation antigen CD6, T12, TP120
BackgroundThe Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes according to their biological activities; Wnts that signal through a Wnt-1/wingless pathway by stabilizing cytoplasmic beta-catenin, and Wnts that stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G protein-dependent manner. Wnt-3a is an intercellular signaling molecule that mediates cytoskeletal reorganization and regulates hippocampal development. Human Wnt-3a is 96% homologous to mouse Wnt-3a protein and 84% homologous to human Wnt-3 protein. The human Wnt-3a gene clusters with the Wnt-14 gene at chromosome 1q42.(EM1706-27)