Von Willebrand Factor Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111990-100µl
$279.00Price

Fig1: Western blot analysis of Von Willebrand Factor on human lung lysates using anti-Von Willebrand Factor antibody at 1/1,000 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Von Willebrand Factor antibody. Counter stained with hematoxylin.

 

Bon Opus Cat. #BA111990
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    von Willebrand factor
  • Background

    Von Willebrand disease is a congenital bleeding disorder caused by defects in the von Willebrand factor protein (VWF). VWF is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets, and it is involved in the coagulation of blood at injury sites. VWF acts as a carrier protein for Factor VIII, a cofactor required for coagulation, and it promotes platelet adhesion and aggregation. Several factors are known to stimulate the binding of VWF to platelets, including glycoprotein 1b, ristocetin, botrocetin, collagen, sulphatides and heparin. Of the several domains contained within VWF, the A1, A2 and A3 domains have been shown to mediate this activation. VWF is thought to undergo a variety of posttranslational modifications that influence the affinity and availability for Factor VII, including cleavage of the propeptide and formation of N-terminal intersubunit disulfide bonds.(ET1701-87)

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