VIL1 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of Villin on human Villin recombinant protein using anti- Villin antibody at 1/1,000 dilution.
Fig2: Western blot analysis of Villin on HEK293 (1) and Villin -hIgGFc transfected HEK293 (2) cell lysate using anti- Villin antibody at 1/1,000 dilution.
Fig3: Western blot analysis of Villin on SW620 cell lysate using anti- Villin antibody at 1/1,000 dilution.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, ICC, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesUbiquitin-conjugating enzyme E2 C, (E3-independent) E2 ubiquitin-conjugating enzyme C, E2 ubiquitin-conjugating enzyme C, UbcH10, Ubiquitin carrier protein C, Ubiquitin-protein ligase C
BackgroundCaldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in non-muscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of Nebulin are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.(EM1706-46)