VE Cadherin Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of VE Cadherin on different lysates using anti-VE Cadherin antibody at 1/1,000 dilution.
Lane 1: Mouse heart
Lane 2: Mouse placenta
Lane 3: Mouse spleen
Lane 4: Mouse lung
Host Species; Species ReactivityRabbit; Mouse
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCadherin-5, Vascular endothelial cadherin, CD_antigen: CD144
BackgroundThe cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. VE-cadherin (for vascular endothelial cadherin, also designated cadherin-5) is localized at intercellular junctions of endothelial cells, where it is thought to play a role in the cohesion and organization of intercellular junctions.(ET1701-93)