UTF1 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on D3 cell lysates (1) and human brain tissue (2) using anti-UTF1 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded human testis tissue using anti- UTF1 rabbit polyclonal antibodies.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesUndifferentiated embryonic cell transcription factor 1
BackgroundUndifferentiated embryonic cell transcription factor 1 (UTF1) is expressed in cells of the inner cell mass and the epiblast. Upon activation by Oct-3/4, UTF1 may be responsible for the rapid proliferation and tumorigenic properties of embryonic stem cells. Sox2 is also part of the Oct-3/4-containing complex able to bind the regulatory region of UTF1. UTF1 acts as a transcriptional coactivator of ATF2 and it binds to the N-terminal region of ATF2. Reduced expression in embryonic stem cells (ESCs) is associated with failure to differentiate properly, although self-renewal is unaffected.(R1305-4)