USP7 Recombinant Rabbit monoclonal Antibody IgG

USP7 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112525-100µl

Fig1: Western blot analysis of USP7 on 293T cell using anti-USP7 antibody at 1/500 dilution.


Fig2: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-USP7 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-USP7 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112525
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein within human USP7 aa 100-200.
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
  • Background

    HAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) is a ubiquitin-specific protease. HAUSP localizes predominantly to the nucleus, in a TD-dependent manner, where it associates with ND10. ND10 are small nuclear structures implicated in a variety of cellular processes including response to stress and interferons, oncogenesis, and viral infection. HAUSP binds strongly to Vmw110, a herpesvirus regulatory protein which has the ability to disrupt ND10. HAUSP, a novel p53-interacting protein, functions to deubiquitinize p53 in an important pathway for p53 stabilization. HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53-dependent cell growth repression and apoptosis. The HAUSP protein is distributed in the nucleus in a micropunctate pattern with a limited number of larger discrete foci, some of which co-localize with PML in ND10. The gene encoding HAUSP maps to human chromosome band 16p13.2.(ET7107-53)

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