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UFO Mouse monoclonal Antibody IgG1

SKU: BA110691-100µl
$279.00Price

Fig1: Western blot analysis of UFO on recombinant protein lysate using anti-UFO antibody at 1/20,000 dilution.

Fig2: ICC staining UFO (green) in SW480 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

 

Bon Opus Cat. #BA110691
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein within human UFO 1-150 aa.
  • Application Summary

    WB, ICC
  • Purification; Formulation

    ProG affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Tyrosine-protein kinase receptor UFO,AXL oncogene
  • Background

    Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. AXL receptor tyrosine kinase has been shown to interact with TENC1.Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.(M1310-5)