UBE2C Mouse monoclonal Antibody IgG2a

UBE2C Mouse monoclonal Antibody IgG2a

SKU: BA112745-100µl
$279.00Price

Fig1: Western blot analysis of UBE2C on human UBE2C recombinant protein using anti-UBE2C antibody at 1/1,000 dilution.

Fig2: Western blot analysis of UBE2C on HEK293 (1) and UBE2C-hIgGFc transfected HEK293 (2) cell lysate using anti-UBE2C antibody at 1/1,000 dilution.

Fig3: Western blot analysis of UBE2C on Hela (1) and Raji (2) cell lysate using anti-UBE2C antibody at 1/1,000 dilution.

Bon Opus Cat. #BA112745
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Kelch repeat and BTB domain-containing protein 8, T-cell activation kelch repeat protein
  • Background

    The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.(EM1706-48)

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